@ Drake:
have you tried going into your INIs?
http://forums.steampowered.com/forums/showthread.php?t=2825612

Six years later and this is still helping people, like me. Thank you so much for the fix. I couldn’t get through this door without crashing. Thank you!

OMG. I already have that thing low and crashes outside the vault. What i am supossed to do now?
FUUUUUUUUUUUCK!

Got me past the part I was crashing on (defend the house with Desmond). Seems like the same problem with Skyrim. It’s like they put too much in to the graphics. So much, that it crashes when you have too much going on, on screen. Like in Skyrim, if I walked in to a cave with a lot of light effects, or in a city at noon, I would get the same type of crash. Same fix, go figure. I hope Bethesda get’s it through their head before they ruin another Fallout. Seriously, I love the game, but I will not spend another dime on their games until I can find a forum saying: Oh wow, they did a great job….

The normal forum input is: bugs bugs bugs bugs bugs bugs bugs… It’s become obvious to me, they have poor talent in the programming department.

Again, thanks for the fix, it did better than the config edit.

The game didnt even started !!i couldnt even see the menu! Dude thank you so much!!!

@ Luke Maciak:
that didnt help for me? my game wont play at all before crashing. the launcher will open, ill click play, and it will go black, and fullscreen like its about to load, and then crash. any ideas?

Yea I am having the same problem but you see there is a minor difference with mine, it is the torrented Game of the Year edition. I would really like some help.

.: STOPPED WORKING – EASY SOLUTION – WINDOWS 7 32bits or 64Bits :.
**********************************************************
Hi, Brothers,
here it goes:

IF YOU ARE USING STEAM…

-> Go to the directory: C:\Program Files (x86)\Steam\steamapps\common\fallout 3 goty
-> Right click on Fallout3.exe > Properties
-> In “compatibility” tab, check the boxes “disable visual themes” and “Disable Desktop Composition”
-> Click “Apply” button
-> Click “Ok” button

That`s It !!!

IF YOU ARE NOT USING STEAM…

-> Go to the Fallout 3 game directory
-> Right click on Fallout3.exe > Properties
-> In “compatibility” tab, check the boxes “disable visual themes” and “Disable Desktop Composition”
-> Click “Apply” button
-> Click “Ok” button

Bye!

@ MKH:
go inside the game and dezactivate the radio

@ Neil:
tri to go inside the game and dezactivate the radio .. that work for me